منابع مشابه
"Aspartame: A review of genotoxicity data".
Aspartame is a methyl ester of a dipeptide of aspartic acid and phenylalanine. It is 200× sweeter than sucrose and is approved for use in food products in more than 90 countries around the world. Aspartame has been evaluated for genotoxic effects in microbial, cell culture and animal models, and has been subjected to a number of carcinogenicity studies. The in vitro and in vivo genotoxicity dat...
متن کاملAspartame m a review
Aspartame (APM), a newly available synthetic sweetener approximately 180-200 times sweeter than sucrose, was approved for marketing by the FDA in 1981 following several years of scientific review. It is available in the United States for use as a sweetener in breakfast cereals, powdered beverages, gelatins, puddings, fillings, whipped toppings, chewing gum, soft drinks and as a table-top sweete...
متن کاملAspartame: review of safety.
Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than people could possibly consume. Its safety was further confirmed through studies in several human subpopulations, includin...
متن کاملGenotoxicity Testing: a Review
Genotoxicity is a major limitation of various compounds used in clinical practices which range from gene mutations, chromosomal aberrations to other DNA effects. For the same reason, it must be assessed before bringing into the market. Moreover, various regulatory agencies have made it mandatory to submit the genotoxicity data while filing a New Drug Application (NDA). This in turn has given fu...
متن کاملGenotoxicity of streptonigrin: a review.
Streptonigrin (SN, CAS no. 3930-19-6) is an aminoquinone antitumor antibiotic isolated from cultures of Streptomyces flocculus. This compound is a member of a group of antitumor agents which possess the aminoquinone moiety and that includes also mitomycin C, porfiromycin, actinomycin, rifamycin and geldanamycin. Because of the potential use of SN in clinical chemotherapy, the study of its genot...
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ژورنال
عنوان ژورنال: Food and Chemical Toxicology
سال: 2015
ISSN: 0278-6915
DOI: 10.1016/j.fct.2015.08.021